| 8 | | One of the challenges of modern neuroscience is integrating voluminous data of diferent |
| 9 | | modalities derived from a variety of specimens. This task requires a common spatial framework |
| 10 | | that can be provided by brain atlases. The first atlases were limited to two-dimentional presentation of structural data. Recently, attempts at creating 3D atlases have been made to offer navigation within non-standard anatomical planes and improve capability of localization of different types of data within the brain volume. |
| | 8 | One of the challenges of modern neuroscience is integrating voluminous |
| | 9 | data of diferent modalities derived from a variety of specimens. This |
| | 10 | task requires a common spatial framework that can be provided by brain |
| | 11 | atlases. The first atlases were limited to two-dimentional |
| | 12 | presentation of structural data. Recently, attempts at creating 3D |
| | 13 | atlases have been made to offer navigation within non-standard |
| | 14 | anatomical planes and improve capability of localization of different |
| | 15 | types of data within the brain volume. |
| 12 | | The 3D atlases available so far have been created using frameworks which make it difficult for other |
| 13 | | researchers to replicate the results. To facilitate reproducible |
| 14 | | research and data sharing in the field we propose a SVG-based Common |
| 15 | | Atlas Format (CAF) to store 2D atlas delineations or other compatible data |
| 16 | | and ''3D Brain Atlas Reconstructor'' (3dBAR), software dedicated to automated |
| 17 | | reconstruction of three-dimensional brain structures from 2D |
| 18 | | atlas data. The basic functionality is provided by 1) a set of parsers |
| 19 | | which translate various atlases from a number of formats into the CAF, |
| 20 | | and 2) a module generating 3D models from CAF datasets. |
| | 17 | The 3D atlases available so far have been created using frameworks |
| | 18 | which make it difficult for other researchers to replicate the |
| | 19 | results. To facilitate reproducible research and data sharing in the |
| | 20 | field we propose an SVG-based Common Atlas Format (CAF) to store 2D |
| | 21 | atlas delineations or other compatible data and 3D Brain Atlas |
| | 22 | Reconstructor (3dBAR), software dedicated to automated |
| | 23 | reconstruction of three-dimensional brain structures from 2D atlas |
| | 24 | data. The basic functionality is provided by 1) a set of parsers which |
| | 25 | translate various atlases from a number of formats into the CAF, and |
| | 26 | 2) a module generating 3D models from CAF datasets. |
| 22 | | This methodology allows for the generation of 3D models in a |
| 23 | | reproducible and configurable manner. The users of the software may |
| 24 | | also track and review the whole reconstruction process in order to |
| 25 | | find and correct errors. |
| 26 | | Our workflow allows for manual corrections to be made when |
| 27 | | automatic reconstruction is not sufficient. |
| | 28 | The whole reconstruction process is reproducible and can easily be |
| | 29 | configured, tracked and reviewed, which facilitates fixing |
| | 30 | errors. Manual corrections can be made when automatic reconstruction |
| | 31 | is not sufficient. The software was designed to simplify |
| | 32 | interoperability with other neuroinformatics tools by using open file |
| | 33 | formats. The content can easily be exchanged at any stage of data |
| | 34 | processing. The framework allows for the addition of new public or |
| | 35 | proprietary content. |